The moment magnitude (M(w)) 7.9 Fort Tejon earthquake of 1857, with a similar to 350-kilometer-long surface rupture, was the most recent major earthquake along the south-central San Andreas Fault, California. Based on previous measurements of its surface slip distribution, rupture along the similar to 60-kilometer-long Carrizo segment was thought to control the recurrence of 1857-like earthquakes. New high-resolution topographic data show that the average slip along the Carrizo segment during the 1857 event was 5.3 +/- 1.4 meters, eliminating the core assumption for a linkage between Carrizo segment rupture and recurrence of major earthquakes along the south-central San Andreas Fault. Earthquake slip along the Carrizo segment may recur in earthquake clusters with cumulative slip of similar to 5 meters.