Catalysis Today, Vol.198, No.1, 345-352, 2012
Biocatalytic reduction of alpha-keto amides to (R)-alpha-hydroxy amides using Candida parapsilosis ATCC 7330
Biocatalytic reduction of primary and secondary alpha-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-alpha-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88-99%) as compared to the secondary (R)-alpha-hydroxy amides. (C) 2012 Elsevier B.V. All rights reserved.
Keywords:Primary alpha-keto amides;Secondary alpha-keto amides;Biocatalytic reduction;(R)-alpha-hydroxy amides;Candida parapsilosis ATCC 7330