The present work deals with improvement in the cooling crystallization of sodium acetate using ultrasonic irradiations. Initially the effect of different operating parameters in the conventional approach such as seeding temperature, seed amount, and initial amount of dissolved sodium acetate has been investigated. It has been found that seeding is essential for the onset of crystallization, and the amount of the seed had a significant effect on the final crystal size distribution and average particle size. Also the seeding temperature affects the type of crystals generated with formation of trihydrate crystals at a temperature higher than 10 degrees C, whereas a seeding temperature of 10 degrees C results in formation of only anhydrous crystals. Experiments under ultrasonic irradiation revealed that the intentional seeding can be avoided using ultrasound provided the irradiation was applied as soon as the cooling is started. The average particle size was found to be dependent on the power dissipation and it decreased with an increase in the irradiation time and power of ultrasound. At low power dissipation levels, unimodal crystal size distribution was obtained. It has been established that the use of ultrasonic irradiation improves the crystallization operation in terms of the avoiding the requirement of intentional seeding and also the final mean crystal size and crystal size distribution can be controlled on the basis of the ultrasound operating parameters.