The solubility of Vitamin D-3 in methanol, ethanenitrile, ethyl ethanoate, ethanol, propan-2-one, and propan-1-ol was measured in the temperature range from (248.2 to 273.2) K by the static equilibrium method. The results revealed that the solubility of Vitamin D3 in solvents was observed to decrease in the order of propan-1-ol > ethanol > ethyl ethanoate > propan-2-one > methanol > ethanenitrile. The minimum mole fraction solubility of 7.61.10(-5) was obtained in ethanenitrile at 248.2 K, while the maximum mole fraction solubility up to 0.193 was obtained in propan-1-ol at 273.2 K. Moreover, the solubility data were correlated with the simplified thermodynamic equation and the modified Apelblat equation, and the calculated solubility for all solvents above was in good agreement with the experimental data in the temperature range of interest.