The effect of temperature on the liquid liquid equilibrium (LLE) of the ternary system of {water (1) + acetic acid (2) + 4-methylpentan-2-one (3)}, a recommended system for liquid liquid extraction studies, was investigated at (288.2, 313.2, and 333.2) K. The reliability of the experimental tie line data was examined with the Othmer-Tobias and the Hand correlations that represented an excellent agreement. The distribution coefficient of acetic acid between organic and aqueous phases increases significantly with temperature, more than 18 % with low solute concentrations, and its value exceeds 1. Meanwhile, a high separation factor within 3.27 to 43.50 was revealed to extract acetic acid from aqueous phase at different temperatures. Higher separations are relevant for low concentrations of acetic acid at 313.2 K. In addition, the binary molecular interaction parameters for the nonrandom two-liquid (NRTL) and the universal quasichemical (UNIQUAC) models were estimated from the experimental results. Results show that these models with their obtained parameters predict tie lines with root-mean square deviation values of 0.0052 and 0.0245, respectively.