The dissociation temperature of clathrate hydrates in the krypton (Kr)-liquid hydrocarbon (methylcyclohexane, MCH and methylcyclopentane, MCP)-water systems was established in the temperature range of (273.2 to 285.6) K and pressure range of (0.5 to 2.4) MPa using optical scanning microscopy. From powder X-ray diffraction data, it was established that the clathrate hydrates formed in the Kr-MCH-water and Kr-MCP-water systems had the structure H (sH). The dissociation pressure-temperature (pT) conditions of the krypton-liquid hydrocarbon-water systems are milder than the pT conditions of Kr hydrate. Large guest molecules captured in the 5(12)6(8) cage affect the phase stability of the sH hydrate when compared to the phase-equilibrium data in the Kr-neohexane-water system.