Solid oxide fuel cells are a promising option for distributed energy stationary power generation that offers efficiencies up to 50% in stand-alone applications, 70% in hybrid gas turbine applications and 80% in cogeneration. To advance SOFC technology sufficiently for widespread market penetration, the SOFC must demonstrate improved cell lifetime from the status quo. Much research has been performed to improve SOFC lifetime using advanced geometries and materials, and in this research, we suggest further improving lifetime by designing an advanced control algorithm based upon preexisting mechanical stress analysis [1]. Control algorithms commonly address SOFC lifetime related operability objectives using unconstrained, SISO control algorithms that seek to minimize thermal transients. While thermal fatigue may be one thermal stress driver, these studies often do not consider maximum radial thermal gradients or critical absolute temperatures in the SOFC. In addition, researchers often discuss hot-spots as a critical lifetime reliability issue, but as previous stress work demonstrates, the minimum cell temperature is the primary thermal stress driver in tubular SOFCs modeled after the Siemens Power Generation, Inc. design. In this work, we present a dynamic, quasi-two-dimensional model for a high-temperature tubular SOFC combined with ejector and prereformer models. The model captures dynamics of critical thermal stress drivers and is used as the physical plant for closed-loop simulations with a constrained, MIMO model predictive control algorithm. Closed-loop simulation results demonstrate effective load-following, operability constraint satisfaction, and disturbance rejection. (C) 2012 Elsevier Ltd. All rights reserved.