A coating of TiC:H was investigated for potential applications as artificial joint materials. Herein, we conducted experimental study using fluid shear method and tribolgoical study to evaluate and analyze the adhesive strength of proteins on TiC:H coatings and Ti6Al4V. Sample surfaces were worn against a steel bearing (E52100) under the lubrication of egg white protein solution. The following wear track and debris analysis helped further understand their wear mechanism. Research results showed that TiC:H coatings on silicon substrate had a porous topography that enhanced its adhesion with the protein. The friction coefficient and wear rate for TiC:H was much lower than Ti6Al4V. This can be attributed to the chemical inertness and functional diamond-like features of TiC:H coatings enhancement in wear resistance, making it superior to Ti6Al4V.