Graphene is exploited to serve as a seamless and inert veil to fabricate a surface-enhanced Raman spectroscopy (SERS) substrate with a passivated surface. This novel approach inherits the concept of metal-molecule isolation (for more well-defined surface interactions) and results in a few superiorities. We find the SERS performance of a graphene-veiled substrate is highly morphology-dependent, and the dynamic process of thermal annealing is investigated in detail by in-situ Raman spectroscopy.