소결공정에 의한 Poly(hydroxypropyl methacrylate) Membrane 제조와 그의 투과특성에 관한 연구

심정섭; 이동권; 홍재민

Journal of the Korean Industrial and Engineering Chemistry, Vol.1, No.2, 147-153, December, 1990

Export Citation

소결공정에 의한 Poly(hydroxypropyl methacrylate) Membrane 제조와 그의 투과특성에 관한 연구

Preparation of Poly(hydroxypropyl methacrylate) Membraney by Sintering Method and Its Permeation Characteristics

심정섭, 이동권, 홍재민

초록

소결공정에 의하여 tertiary amine을 함유하는 hydroxypropyl methacrylate 고분자막을 제조하였다. 이 막의 함수율은 수용액의 pH가 감소함에 따라 증가하였다. 인슐린의 투과도 역시 수용액의 pH가 감소함에 따라 증가하였다. 이 막의 투과도는 소결 압력이 증가함에 따라 감소하였다. 이 막에 당산화효소를 고정화시킨 acryl amide막을 부착하여 복합 matrix device를 제조하였다. 이 막의 인슐린 투과도는 glucose의 농도가 증가함에 따라 증가하였다.

Poly(hydroxypropyl methacrylate) membranes and matrix devices having tertiary amine moiety were prepared by sintering method, and their permeation characteristics were investigated. The water content of this membrane was increased with decreasing the pH of the medium. The permeability of this membrane was increased with decreasing the sintering pressure. Using sintered matrix device 'burst effect' was found at the early stage, and initial insulin release of glucose oxidase immobilized matrix device could be controlled by glucose concentration of the solution.

[References]

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[1] Chiasson JL, Ducros F, Diabetes Care, 7(4), 331 (1984)

[2] Creque HM, Langer R, Folkman J, Diabetes, 29, 37 (1980)

[3] Brownlee M, Cerami A, Science, 206, 1190 (1979)

[4] Alhaique F, Marchetti M, Riccieri FM, Santucci E, J. Pharamcol., 33, 413 (1981)

[5] Ishihara K, Kobayashi M, Shinohara I, Polym. J., 16, 647 (1984)

[6] Hicks GD, Updike SJ, Anal. Chem., 38, 726 (1966)

[7] Saka Y, Tanazawa H, J. Appl. Polym. Sci., 22, 1805 (1978)

[8] Yasuda H, Lamaze CE, Ikenberry LD, Makromol. Chem., 118, 19 (1968)

[9] Langer R, Peppas NA, Macromol. Sci., 23, 61 (1983)

[10] Robert CR, Buri PA, Peppas NA, J. Appl. Polym. Sci., 30, 301 (1985)

[11] Franson NM, Peppas NA, J. Appl. Polym. Sci., 28, 1299 (1983)

[12] Updike SJ, Schultz M, Diabetes Care, 5, 207 (1982)

[13] Peppas NA, Buri P, Doekler E, Int. J. Pharm., 15, 25 (1983)

[14] Hong JM, Shim JS, J. Korean Ind. Eng. Chem., 1(2), 154 (1990)