Biodegradable polymers of poly(lactic acid) (PLLA) and synthesized in-house poly(trimethylene carbonate) (PTMC) with admixture of water-soluble methyl cellulose (MC) were used for development of nerve guidance tubes for peripheral nervous system regeneration after injury. Fabrication method involved phase separation of viscous dixane solution of polymers mixture seat on a rod in a proper nonsolvent, which resulted in tubular structure of large porosity. Influence of electron beam sterilization on molecular weight, thermal properties of the polymers, and mechanical performance of the tubes was evaluated. Admixture of hydrophilic MC to synthetic polymers resulted in modification of mechanical properties of the channels. Extraction of MC showed potential of the tubes for releasing water-soluble bioactive molecules, such as for instance growth factors. Basic in vitro MTT and LDH assays showed no cytotoxic effect of manufactured tubes, therefore, animal experimentations may be considered. (c) 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013