1-Paimitoyl-sn-glycero-3-phosphocholine was esterified with geranic, (E)-3,7-dimethyloct-4-enoic, (2E, 8E)-3,7,11-trimethyldodeca-2,8-dienoic and (4E, 8Z)-5,9,13-trimeth-yltetradeca-4,8,12-trienoic acids in presence of N,N'-dicyclohexylcarbodiimide and 4-dimethylaminopyridine to prep. 4 resp. new 1,2-diacylphosphatidylcholines with isoprenoid residues in sn-2 position as prospective anticancer agents.