After deposition, solution processed macromolecules are susceptible to redissolution by similar solvents. This “solvent problem” puts undesirable restrictions on the subsequent processing of organic devices; particularly when forming multiple layers or using organic patterning materials. In this review we survey the creative approaches seeking to resolve the solvent problem. We conclude that two of these approaches show promise as comprehensive solutions; use of orthogonal solvents such as hydofluoroethers, and, use of cross-linking additives. Furthering development of these or other approaches provides the community with plentiful opportunity for valuable future work.