Lithium-ion batteries have been long considered a promising energy storage technology for electrification of the transportation system. However, the poor safety characteristics of lithium-ion batteries is one of several technological barriers that hinder their deployment for automobile applications. Within the field of battery research and development, titanium-based anode materials have recently attracted widespread attention due to their significantly better thermal stability than the conventional graphite anode. In this chapter, the fundamental properties and promising electrochemical performance of titanium-based anode materials will be discussed for applications in hybrid electric vehicles.