화학공학소재연구정보센터
Atomization and Sprays, Vol.22, No.9, 715-731, 2012
EVALUATION OF SPRAY EVOLUTION IN PHARMACEUTICAL TABLET COATING PROCESSES: THE EFFECTS OF DRUM ROTATIONAL SPEED AND DRYING AIR FLOW RATE ON SPRAYS' CHARACTERISTICS
Sprays produced by a pharmaceutical nozzle were characterized in a 120 cm (24 in.) diameter tablet pan-coater at four different sets of operating conditions: stationary drum with drying air turned on/off, and 8 rpm rotating drum with drying air turned on/off. Turning drying air on resulted in up to a 6 m/s increase in drop velocity, but had mixed effects on drop size. When the spray gun produced mostly small drops (D-10 < 10 mu m), supplying drying air to the drum led to an increase in D-32. The reverse was observed when the spray was composed of mostly large drops. Both observations likely arose from drop evaporation. Supplying drying air also reduced spray extent and volume flux magnitude. Adding drum rotation generally led to (i) increased drop size and (ii) decreased drop velocity. Condition (i) likely arose from the transport of small drops away from the spray zone, while (ii) likely resulted from changes in droplet trajectories. Both resulted from gas-phase swirling that was induced by the drum rotation. The influence of drum rotation on drop velocity diminished when drying air flow was included as the drying air momentum helped the drops oppose the effects of the drum rotation-induced swirling flow.