Vapor-liquid equilibrium (VLE), excess molar enthalpies (H-E), and excess molar volumes (V-E) provide complementary data for thermodynamic models. In this work, new data of binary mixtures of acetonitrile (ACN) or propanenitrile (PPN) with 2-ethoxy-2-methylpropane (ETBE) or 2-ethoxy-2-methylbutane (TAEE) are reported. Isothermal VLE data were measured by using a circulation still at 333 K for ETBE + ACN, at 343 K for TAEE + ACN, and at 363 K for TAEE + PPN. H-E were measured by using a SETARAM C80 calorimeter equipped with a flow mixing cell at 298 K for all four binary systems. V-E were measured by using an Anton Paar DMA 512P densimeter at 298 K for all four binary systems. H-E data and measured VLE data, or literature VLE data for the binary system of ETBE and PPN, were used for the optimization of Wilson model parameters by using VLEFIT software. Redlich-Kister equation parameters were separately regressed for the V-E data.