Organic-inorganic hybrid nanocomposites were prepared via in situ sol-gel process. The organic phase is a biodegradable polymer, poly(epsilon-caprolactone) (PCL), while the tetrabutyl titanate (TBT, Ti(OBu)(4)) was used as inorganic precursor. Synthesis parameters like acidity medium and precursor amount were investigated in order to assess their influence on hybrid properties. The obtained nanocomposites were characterised by thermal analysis, spectroscopic techniques, transmission electronic microscopy (TEM) and X-ray diffraction to gather information on the structure of the nanocomposites. Mechanical properties and biodegradability were also evaluated. A reaction mechanism based on Fourier transform infrared spectroscopy and NMR results was proposed using methyl acetate as model compound. TEM micrographs of the nanocomposites show a fine good nanoparticles dispersion. Acidic conditions and 10 wt% of precursor lead to a nanocomposite with higher mechanical properties and biodegradability than PCL.