The selective reduction of NO by C3H8 is performed on copper-based catalysts, fresh and hydrothermally Cu-MFI with various Si/Al ratios and copper contents, Cu on conventional nonzeolitic supports with various Cu loadings. In the literature it is already known that the C3H8 oxidation by NO occurs mainly on isolated copper ions. However, the sites responsible for the C3H8 oxidation by O-2 are less studied. This note shows that nonisolated copper ions are active for the C3H8 oxidation by O-2. With or without NO in the feed, bulk oxides are more active for the C3H8-O-2 reaction than for the C3H8-NO (or NO2) reaction. Furthermore, NO inhibits the hydrocarbon combustion by O-2.