화학공학소재연구정보센터
Journal of the American Chemical Society, Vol.135, No.12, 4700-4703, 2013
Building Biologics by Chemical Synthesis: Practical Preparation of Di-and Triantennary N-Linked Glycoconjugates
A unified strategy for the syntheses of bi- and triantennary fully sialylated N-glycans is described. The synthesis capitalizes on a global glycosylation strategy that delivers the desired undeca- and tetradecasaccharide in excellent yields. Finally, conjugation of the glycan to PSMA oligopeptide is described.