Journal of the American Chemical Society, Vol.135, No.12, 4716-4718, 2013
Rhodium-Catalyzed Conversion of Furans to Highly Functionalized Pyrroles
The synthesis of highly functionalized pyrroles has been achieved by reaction of rhodium-stabilized imino-carbenes with furans. The reaction features an initial [3+2] annulation to form bicyclic hemiaminals, followed by ring opening to generate trisubstituted pyrroles.