In continuation to our efforts in finding potential therapeutic agents, a series of biologically significant poly(azomethine)esters (fe-PAME) were synthesized by the reaction of preformed (E)-4-((4-hydroxyphenylimino)methyl)phenol (SB) with 1,1-di(chlorocarboxyl)ferrocene, (PFe). Different aliphatic and aromatic sequences (1,3-propandiol, 1,6-hexandiol, and poly(dimethylsiloxane), hydroxyl-terminated (n = 550), 1,1,1,3,3,3-hexafluorobis(phenol)propane, and bisphenol A) were incorporated in the parent chain to study their effect on biological activity. The overall results led to the identification of some interesting polymers which seem to be potent antioxidants, highly cytotoxic, and more importantly DNA protecting and hence can be studied further for other pharmacological activities to be used as potential drug candidates FTIR and H-1 NMR spectroscopic studies and elemental analysis were used to establish structural elucidation and structure property relations. Laser light scattering was used to determine molecular parameters.