Silver nanomaterials have been extensively investigated due to their unique optical and biological properties. Surface plasmons and scattering phenomena occurring on silver nanostructures can provide useful analytical or sensor platform. Here, we present silver nanoparticles preferentially reduced on polyethylene glycol (PEG)-grafted glass surfaces for application to surface-enhanced Raman scattering (SERS). Uniform silver nanoparticles of similar to 50 nm size were easily generated by dipping the PEG-grafted glass surfaces in silver salt solution at room temperature without any additional reducing agent. The silver nanoparticles generated on the PEG-grafted surfaces were confirmed by AFM and FE-SEM analysis. (C) 2013 Elsevier Ltd. All rights reserved.