The influence of the preparation procedure of Fe- and In-containing zeolites on their physicochemical and catalytic properties in methanol conversion to hydrocarbons and the upgrading of the straight-run gasoline fraction of crude oil has been studied. The introduction of In and Fe into a zeolite increases the on-stream time of the catalysts in methanol conversion and increases their selectivity for the formation of alkenes and isoalkanes. Zeolites containing iron and indium nanopowders are the most effective catalysts for the manufacturing of high-octane gasolines from straight-run gasoline.