The aim of this work was to examine the influence of the concentration of chloride, nitrate, perchlorate, and zinc(II) ions in the extraction process using synthesized hydrophobic 2-pyridyl ketoximes. Results indicated that oximes could extract zinc(II) ions from chloride solutions and that the extraction depended on ligand and chloride ion concentrations. A maximum extraction was observed at 1.01.5 M Cl- and at higher chloride solutions the complex-forming power of 2-pyridyl ketoximes slowly decreased. Zinc(II) ions were effectively stripped from the loaded organic phase with water or ammonia solutions in two stages. The regenerated oximes could yet be used again in the extraction of zinc(II) ions and the reagents could be able to extract solutions with similar results as before. The current study shows that 2-pyridyl ketoximes can be used to extract zinc(II) ions from concentrated chloride solutions and that the separation of copper(II) ions from multielemental solutions is possible.