화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.30, No.7, 1359-1367, July, 2013
DOI10.1007/s11814-013-0083-y  Export Citation
Viruses as self-assembled nanocontainers for encapsulation of functional cargoes
Yuanzheng Wu1, 2, Hetong Yang2, and Hyun-Jae Shin1, †
  • 1Department of Chemical and Biochemical Engineering, Chosun University, 375, Seosuk-dong, Dong-gu, Gwangju 501-759, Korea
  • 2Biotechnology Center of Shandong Academy of Sciences, No. 19 Keyuan Road, Jinan 250014, China
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Viruses naturally exhibit an incredible variety of sophisticated nanostructures, which makes them ideal biological building blocks for nanoengineered material research. By mimicking their spontaneous assembly process, tremendous advances have been made towards utilizing virus and virus-like particles (VLPs) as protein cages, scaffolds, and templates for nanomaterials in the last few years. This review outlines recent progress in the field of bionanotechnology in which viruses are introduced to encapsulate various functional cargoes in a precise and controlled fashion. The encapsulation mechanisms are summarized into three main strategies: electrostatic interaction, chemical conjugation, and covalent attachment by genetic manipulation. The combination with chemical modification and genetic engineering heralds a brilliant future for fabrication of functional nanomaterials. These well-defined architectures will find attractive applications in biosensing, drug delivery, enzyme confinement, light-harvesting system, and pharmaceutical therapy.
Keywords:Virus;Virus-like Particles (VLPs);Encapsulation;Nanomaterials;Drug Delivery
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