화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.21, No.7, 747-756, July, 2013
DOI10.1007/s13233-013-1078-6  Export Citation
Preparation and non isothermal crystallization kinetic of acetylsalicylic acid-poly(vinylalcohol-co-ethylene) blend. Application in drug delivery domain
Norah Mubarak Alotaibi, and Taieb Aouak†
  • Chemistry Department, Faculty of Science, King Saud University, Riyadh, 11459, Saudi Arabia
E-mail:
A series of acetylsalicylic acid-poly(vinylalcohol-co-ethylene) blends (AcSa/PVAE) of different compositions were prepared by dissolution and solvent evaporation then characterized by the solubility test, differential scanning calorimetry (DSC), X-ray diffractometer (XRD) and by scanning electron microscopy (SEM) analyses. The results revealed that AcSa was perfectly soluble in PVAE up to a certain composition. A non-isothermal study of the crystallization kinetic of AcSa/PVAE materials was carried out by the DSC method. It was observed that the Ozawa equation perfectly describes the primary process of non-isothermal crystallization of this material. There is a strong dependence of AcSa/PVAE composition on the crystallization parameters. In general, at any cooling rate the variation in t 1/2 of crystallization vs. the AcSa/PVAE composition passed by a minimum then a maximum of 7 and 5 wt% of AcSa, respectively. The crystallization activation energy (E a ) calculated from the Kissinger model reached a maximum when the concentration of AcSa in the AcSa/PVAE system was 8.5 wt%. The release dynamic of AcSa from AcSa/PVAE material was tested at body temperature during 92 h. On the light of the data obtained, it was found that at pH 5 and 7, AcSa/PVAE 15 presented the best performance because this material was capable of releasing more than 50 wt% of the AcSa amount uniformly (1.30±0.8 wt%/h) during 38-39 h.
Keywords:poly(vinylalcohol-co-ethylene);acetylsalicylic acid;blend;non-isothermal;crystallization kinetic;drug release
  1. Keskin SU, Elliott JR, Ind. Eng. Chem. Res., 42(25), 6331 (2003)
  2. Tomita K, Kojoh K, Suzuki A, J. Ferment. Bioeng., 84(5), 400 (1997)
  3. Mejia AI, Lopez BL, Sierra L, Mater. Res. Innov., 4, 148 (2001)
  4. Lopez BL, Mejia AI, Sierra L, Polym. Eng. Sci., 39(8), 1346 (1999)
  5. Mejia AI, Lopez BL, Muler A, Macromol. Chem. Phys. Symp., 148, 131 (1999)
  6. Young TH, Chuang WY, Wei CW, Tang CY, J. Membr. Sci., 191(1-2), 199 (2001)
  7. Raderick PJ, Wilkes HG, Meade TW, Br. J. Clin. Pharmacol., 35, 219 (1993)
  8. Holliday WM, Berdrick M, Bell SA, Kiritsis GC, US Patent 3,488,418 (1970).
  9. Powel TC, Steinte ME, Yoncoskie RA, US Patent 3,415,758 (1968).
  10. Dash V, Mishra SK, Singh M, Goyal AK, Rath G, Sci. Pharm., 78, 93 (2010)
  11. Amperiadou A, Georgarakis M, Int. J. Pharm., 115, 1 (1995)
  12. Takada S, Kurokawa T, Iwasa S, US Patent 6,117,455 (1995).
  13. Jaya S, Durance TD, Wang R, Open Biomater. J., 2, 9 (2010)
  14. Polk A, Amsden B, Deyao K, Peng T, Goosen MFA, J. Pharm. Sci., 83, 178 (1994)
  15. Gonzalez M, Rieumont J, Dupeyron D, Perdomo I, Fernandez E, Abdon L, Castano VM, Rev. Adv. Mater. Sci., 17, 71 (2008)
  16. Hazneder S, Dortunc B, Int. J. Pharm., 269, 131 (2004)
  17. Rao VM, Engh K, Qiu Y, Int. J. Pharm., 252, 81 (2003)
  18. Ferrero CI, Bravo M, Jimenez R, J. Control. Release, 92, 69 (2003)
  19. Chen W, Lu DR, J. Microencapsul., 16(5), 551 (1999)
  20. Lin WJ, Wu TL, J. Microencapsul., 16(5), 639 (1999)
  21. Jenquin MR, Liebowitz SM, Sarabia RE, McGinity JW, J. Pharm. Sci., 79, 811 (1990)
  22. Gavhane YN, Shinde VR, Mudannapatil PB, Yadav AV, Arch. Pharm. Sci. Res., 1, 75 (2009)
  23. Zhuang YF, Yang H, Wang GW, Zhu ZQ, Song WQ, Zha HD, J. Appl. Polym. Sci., 88(3), 724 (2003)
  24. Smitha B, Suhanya D, Sridhar S, Ramakrishna M, J. Membr. Sci., 241(1), 1 (2004)
  25. Yoshitaka N, Nakano T, Okamoto Y, Gotoh Y, Nagura M, Polymer, 42(24), 9679 (2001)
  26. Ikejima T, Yoshie N, Inoue Y, Polym. Degrad. Stabil., 66, 263 (1999)
  27. Jang J, Lee DK, Polymer, 44(26), 8139 (2003)
  28. Anwar MK, Agarwal SP, Ali A, Sultana Y, J. Incl. Phenom. Macrocycl. Chem., 67, 209 (2010)
  29. Guadagno L, Naddeo C, Vittoria V, Camino G, Cagnani C, Polym. Degrad. Stabil., 72, 175 (2001)
  30. Peng Z, Kong LX, Li SD, Polymer, 46(6), 1949 (2005)
  31. Hao W, Yang W, Cai H, Huang Y, Polym. Test, 29, 527 (2010)
  32. Hammami A, Spruiell JE, Mehrotra AK, Polym. Eng. Sci., 35(10), 797 (1995)
  33. Ozawa T, Polymer, 12, 150 (1971)
  34. Jeziorny A, Polymer, 19, 1142 (1978)
  35. Ziabicki A, Colloid Polym. Sci., 274, 209 (1996)
  36. Ziabicki A, Colloid Polym. Sci., 274, 705 (1996)
  37. Shi XM, Zhang J, Jin J, Chen SJ, eXPRESS Polym. Lett., 2, 623 (2008)
  38. Huang H, Gu LX, Ozaki Y, Polymer, 47(11), 3935 (2006)
  39. Chivrac F, Pollet E, Averous L, J. Polym. Sci. B: Polym. Phys., 45(13), 1503 (2007)
  40. Kalkar AK, Deshpande AA, Polym. Eng. Sci., 41(9), 1597 (2001)
  41. Avrani MJ, J. Chem. Phys., 7, 1103 (1939)
  42. Alvarez VA, Stephani PM, Vazquez A, J. Therm. Anal. Calorim., 79, 187 (2005)
  43. Pratt CF, Hobbs SY, Polymer, 17, 12 (1976)
  44. Francis AA, J. Am. Ceram. Soc., 88(7), 1859 (2005)
  45. Kissinger HE, J. Res. Natl. Bur. Stand., 57, 217 (1956)