화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.21, No.8, 833-842, August, 2013
DOI10.1007/s13233-013-1101-y  Export Citation
Heterogeneous mesoporous SBA-15 silica as catalyst towards the synthesis of various biodegradable aliphatic polyesters
Sakthivel Gandhi, Swaminathan Sethuraman, and Uma Maheswari Krishnan†
  • Centre for Nanotechnology & Advanced Biomaterials, School of Chemical & Biotechnology, SASTRA University, Thanjavur, 613 401, India
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Biocompatible and biodegradable polyesters have immense potential in medical applications as drug delivery vehicles and tissue engineering scaffolds. In this study, we synthesized biodegradable aliphatic polyesters, namely poly(butylene pimelate) (PBPi), poly(butylene succinate) (PBSu), and poly(butylene sebacate) (PBSe), by the polycondensation of equimolar quantities of dicarboxylic acid and diol using mesoporous SBA-15 silica as heterogeneous catalyst. We then compared its performance with a conventional homogenous catalyst, SnCl2·2H2O, which did not form these polymers. The synthesized SBA-15 catalyst was characterized by electron microscopy, nitrogen adsorption-desorption isotherm and infrared spectroscopy. The synthesized polyesters were evaluated using infrared spectroscopy, X-ray diffraction, nuclear magnetic resonance spectroscopy, differential scanning calorimetry, gel permeation chromatography, scanning electron microscopy and goniometry. The combined results demonstrate that the SBA-15 mesoporous catalyst formed higher molecular weight degradable polyesters in addition to higher yield and purity, thus confirming the superiority of the mesoporous silica catalyst for polymer formation.
Keywords:heterogeneous catalyst;SBA-15;aliphatic polyester;microspheres
  1. Ward MA, Theoni KG, Polymer, 3, 1215 (2011)
  2. Kuppan P, Vasanthan KS, Sundaramurthi D, Krishnan UM, Sethuraman S, Biomacromolecules, 12(9), 3156 (2011)
  3. Dhandayuthapani B, Krishnan UM, Sethuraman S, J. Biomed. Mater. Res. A, 94, 264 (2010)
  4. Tian H, Tang Z, Zhuang X, Chen X, Jing X, Prog. Polym. Sci, 37, 237 (2012)
  5. Huh KM, Kang HC, Lee YJ, Bae YH, Macromol. Res., 20(3), 224 (2012)
  6. Sethuraman S, Nair LS, El-Amin S, Farrar R, Nguyen MTN, Singh A, Allcock HR, Greish YE, Brown PW, Laurencin CT, J. Biomed. Mater. Res. A, 77, 679 (2006)
  7. Lakshmi S, Katti DS, Laurencin CT, Adv. Drug Deliv. Rev., 55, 467 (2003)
  8. Laurencin CT, Gerhart T, Witschger P, Satcher R, Domb A, Rosenberg AE, Hanff P, Edsberg L, Hayes W, Langer R, J. Orthop. Res., 11, 256 (1993)
  9. Zahedi P, Rezaeian I, Ranaei-Siadat SO, Jafari SH, Supaphol P, Polym. Adv. Technol., 21, 77 (2010)
  10. De Groot JH, De Vrijer R, Pennings AJ, Klompmaker J, Veth RP, Jansen HW, Biomaterials, 17, 163 (1996)
  11. Kopinkea FD, Remmlera M, Mackenziea K, Modera M, Wachsen O, Polym. Degrad. Stabil., 53, 329 (1996)
  12. Sethuraman S, Nair LS, Amin SE, Nguyen MT, Singh A, Krogman, Greish YE, Allcock HR, Brown PW, Laurencin CT, Acta Biomater., 6, 1931 (2010)
  13. Serrano MC, Pagani R, Vallet-Regi M, Pena J, Ramila A, Izquierdo I, Portoles MT, Biomaterials, 25, 5603 (2004)
  14. Luo L, Wei X, Chen GQ, J. Biomater. Sci., 20, 2537 (2009)
  15. Khang G, Rhee JM, Jeong JK, Lee JS, Kim MS, Cho SH, Lee HB, Macromol. Res., 11(4), 207 (2003)
  16. Lydon MJ, Minett TW, Tighe BJ, Biomaterials, 6, 396 (1985)
  17. Simone CM, de Fatima VMM, Eur. Polym. J., 37, 2123 (2001)
  18. Hegedus A, Hell Z, Vargadi T, Potor A, Gresits I, Catal. Lett., 17, 99 (2007)
  19. Corma A, Nemeth LT, Renz M, Valencia S, Nature, 412, 423 (2001)
  20. Lesaint C, Glomm WR, Borg O, Eri S, Rytter E, Oye G, Appl. Catal. A: Gen., 351(1), 131 (2008)
  21. De Rosa C, Auriemma F, Spera C, Talarico G, Gahleitner M, Polymer, 45(17), 5875 (2004)
  22. Allenger VM, McLean DD, Ternan M, J. Catal., 131, 305 (1991)
  23. Lee IS, Kwak YW, Lee HD, Gal YS, J. Ind. Eng. Chem., 14(6), 720 (2008)
  24. Wei ZY, Liu L, Qi M, React. Funct. Polym., 66(12), 1411 (2006)
  25. Zeng JB, Li YD, Zhu QY, Yang KK, Wang XL, Wang YZ, Polymer, 50(5), 1178 (2009)
  26. Ishihara K, Nakayama M, Ohara S, Yamamoto H, Tetrahedron, 58, 8179 (2002)
  27. Nagai A, Sato D, Ishikawa J, Ochiai B, Kudo H, Endo T, Macromolecules, 37(7), 2332 (2004)
  28. Takasu A, Iio Y, Oishi Y, Narukawa Y, Hirabayashi T, Macromolecules, 38(4), 1048 (2005)
  29. Corma A, Kumar D, Stud. Surf. Sci. Catal., 117, 201 (1998)
  30. Chiu JJ, Pine DJ, Bishop ST, Chmelka BF, J. Catal., 221(2), 400 (2004)
  31. Corma A, Chem. Rev., 95(3), 559 (1995)
  32. Tanabe K, Holderich WF, Appl. Catal. A: Gen., 181(2), 399 (1999)
  33. Bellussi G, Pazzuconi G, Perego C, Girotti G, Terzoni G, J. Catal., 157(1), 227 (1995)
  34. Perego C, Amarilli S, Carati A, Flego C, Pazzuconi G, Rizzo C, Bellussi G, Microporous Mesoporous Mater., 27, 345 (1999)
  35. Zhao W, Salame P, Launay F, Gedeon A, Hao Z, J. Porous Mat., 15, 139 (2008)
  36. Kim KS, Song JH, Kim JH, Seo G, Stud. Surf. Sci. Catal., 146, 505 (2003)
  37. Liang C, Li Z, Dai S, Angew. Chem.-Int. Edit., 47, 3696 (2008)
  38. Zheng JY, Pang JB, Qiu KY, Wei Y, Microporous Mesoporous Mater., 49, 189 (2001)
  39. Qiao ZA, Zhang L, Guo M, Liu Y, Huo Q, Chem. Mater., 21, 3823 (2009)
  40. Kim P, Kim Y, Kim C, Kim H, Park Y, Lee JH, Song IK, Yi J, Catal. Lett., 89(3-4), 185 (2003)
  41. Chandra D, Mridha S, Basak D, Bhaumik A, Chem. Commun., 17, 2384 (2009)
  42. Selvam P, Krishna NV, Viswanathan B, J. Indian Inst. Sci., 90, 271 (2010)
  43. Bhagiyalakshmi M, Do Park S, Cha WS, Jang HT, Appl. Surf. Sci., 256(22), 6660 (2010)
  44. Lu QY, Gao F, Komarneni S, Mallouk TE, J. Am. Chem. Soc., 126(28), 8650 (2004)
  45. Snead OC, Furner R, Liu CC, Biochem. Pharmacol., 38, 4375 (1989)
  46. Griffith RS, Norins AL, Kagan C, Dermatologica, 156, 257 (1978)
  47. King A, Selak MA, Gottlie E, Oncogene, 25, 4675 (2006)
  48. Halarnkar PP, Blomquist GJ, Comp. Biochem. Physiol. B: Biochem. Mol. Biol., 92, 227 (1989)
  49. Sugihara S, Toshima K, Matsumura S, Macromol. Rapid Commun., 27(3), 203 (2006)
  50. Linko YY, Wang ZL, Seppal J, J. Biotechnol., 40, 133 (1995)
  51. Panova AA, Kaplan DL, Biotechnol. Bioeng., 84(1), 103 (2003)
  52. Velmathi S, Nagahata R, Sugiyama J, Takeuchi K, Macromol. Rapid Commun., 26(14), 1163 (2005)
  53. Chen CH, Yang CS, Chen M, Shih YC, Hsu HS, Lu SF, eXPRESS Polym. Lett., 5, 284 (2011)
  54. Sasidharan M, Mal NK, Bhaumik A, J. Mater. Chem., 17, 278 (2007)
  55. Gandhi S, Sethuraman S, Krishnan UM, J. Porous Mat., 18, 329 (2011)