The density, viscosity, refractive index for the sodium D-line, and speed of sound in binary mixtures of water with N,N-dimethylformamide, dimethyl sulfoxide, N,N-dimethylacetamide, acetonitrile, ethylene glycol, diethylene glycol, 1,4-dioxane, tetrahydrofuran, 2-methoxyethanol, and 2-ethoxyethanol have been determined at 298.15 K over the whole range of mixture compositions. From these results, the excess molar volume, deviations in viscosity, speed of sound, molar refractivity, and isentropic compressibility have been calculated. The computed results are fitted to the Redlich-Kister polynomial equation to estimate the adjustable parameters and standard deviations. The observed negative V-E values are compared with the available literature results.