We focus on the development of a Lyapunov-based economic model predictive control (LEMPC) method for nonlinear singularly perturbed systems in standard form arising naturally in the modeling of two-time-scale chemical processes. A composite control structure is proposed in which, a "fast" Lyapunov-based model predictive controller (LMPC) using a quadratic cost function which penalizes the deviation of the fast states from their equilibrium slow manifold and the corresponding manipulated inputs, is used to stabilize the fast dynamics while a two-mode "slow" LEMPC design is used on the slow subsystem that addresses economic considerations as well as desired closed-loop stability properties by utilizing an economic (typically non-quadratic) cost function in its formulation and possibly dictating a time-varying process operation. Through a multirate measurement sampling scheme, fast sampling of the fast state variables is used in the fast LMPC while slow-sampling of the slow state variables is used in the slow LEMPC. Appropriate stabilizability assumptions are made and suitable constraints are imposed on the proposed control scheme to guarantee the closed-loop stability and singular perturbation theory is used to analyze the closed-loop system. The proposed control method is demonstrated through a nonlinear chemical process example. (C) 2013 Elsevier Ltd. All rights reserved.