This work considers enhancing the stability and improving the economic performance of nonlinear model predictive control in the presence of disturbances or model uncertainties. First, a robust control Lyapunov function (RCLF)-based predictive control strategy is proposed. Second, the approximate dynamic programming (ADP) is employed to further improve regulation performance. Finally, the ADP and RCLF-MPC are combined to provide a switching control scheme, which is illustrated on a CSTR example to show its effectiveness. (C) 2013 Elsevier Ltd. All rights reserved.