Experimental results for the partition coefficient of 41 substances (several phenol, indole, biphenyl, and naphthalene derivates, polycyclic aromatic compounds, and polyfunctional haloaromatics) in hexane + water at 298.15 K are reported. Partition coefficients were measured by reversed phase high-performance liquid chromatography and the shake-flask method. The experimental results are compared successfully to predictions by the linear solvation energy relationship method.