키토산 유도체를 이용한 약물 방출 조절

차월석; 김선일; 이동병; 나재운

Journal of the Korean Industrial and Engineering Chemistry, Vol.6, No.1, 8-14, February, 1995

Export Citation

키토산 유도체를 이용한 약물 방출 조절

Control of Drug Release Using Chitosan Derivatives

차월석, 김선일, 이동병, 나재운

초록

약물 전달체에 prednisolone을 분산시켜 제조한 고분자 매트릭스를 pH 1.2 및 pH 7.4 완충용액에서 약물 방출실험을 하였다. 약물 방출시간은 pH 1.2보다 pH 7.4에서 더 지연되었으며 약물 전달체의 함유량이 증가함에 따라 약물 방출시간도 지연되었다. 이러한 거동은 약물전달체가 산성에서 팽윤을 더 잘하기 때문이다. 약물 전달체의 종류에 따라 지연된 약물 방출시간은 키토산 고분자 매트릭스의 경우가 가장 길었으며, 술폰화키토산 고될자 매트릭스, 키토산 · 염 고분자 매트릭스의 순서였다. 특히 이러한 제형들은 초기 방출속도를 억제하는 팽윤성 방출조절형 제제임을 확인할 수 있었다.

The release experiments of drug were operated In the buffer solutions of pH 7.4 and pH 1.2 by using drug carriers with prednisolone for delivery drug. The release time of drug was more delayed in pH 7.4 than in pH 1.2. The reason is that drug carriers have greater swelling abilities at low pH than at high pH. The release time of drug carriers was delayed in the order of chitosan polymeric malrlx, sulfonated chitosan polymeric matrix, and chitosan hydrochloride polymeric matrix. In short, the fomulation allows polymeric matrix to supress the burst effect of the drug release mechanism, which led to the controlled release pattern by swelling.

[References]

Wolform ML, Madison RK, Cron MJ, J. Am. Chem. Soc., 74, 1491 (1952)
Hackman RH, Austr. J. Biol. Sci., 7, 168 (1954)
Kurida K, Sannan T, Iwakura Y, Makromol. Chem., 178, 3197 (1977)
Miyazaki T, Matsushima Y, Bull. Chem. Soc. Jpn., 41, 2723 (1968)
Nudge La, Plisko EA, Danilov SN, Zh. Obshch. Khim., 45, 1145 (1975)
Kaifu K, Nishi N, Komai T, Polym. J., 13, 214 (1981)
Jeuniaux C, Arch. Intern. Physiol. Biochem., 72, 329 (1964)
Muzzarelli RAA, "Chitin," 46, Pergamon, New York (1977)
Guy RH, Hadgraft J, "Drug Parameters Important for Transdermal Delivery," vol. III, 4 ~ 5, CRC Press, Florida (1987)
Noonan PK, Bend LZ, Int. J. Pharm., 12(4-5), 331 (1982)
Kim SI, Na JW, J. Korean Chem. Soc., 37, 527 (1993)
Miayzaki S, Ishii K, Nodai T, J. Korean Chem. Soc., 29, 3067 (1981)
Sawayanagi Y, Nambu N, Nagi T, J. Korean Chem. Soc., 31, 2064 (1983)
Sheth PR, Tossounian JL, U.S. Patent, 4,140,755 (1990)
Shalaby WSW, Blevins WE, Park KN, Proc. Int. Symp. Control. Rel. Bioact. Mater., 17, 134 (1990)
Curatolo WJ, Lo J, Eur. Patent, 0,344,939 A2 (1992)
Johson P, Lioyd-Jones JG, "Drug Delivery Systems," 107, Ellis Horwood, England (1984)
Rouget C, Comp. Rend., 48, 792 (1859)
Rigby GW, U.S. Patent, 2,072,771 (1936)
Kim YM, Choi KS, Polym.(Korea), 9(5), 417 (1985)
Wolfrom ML, ShenHan TM, J. Am. Chem. Soc., 81, 1764 (1959)
Sannan T, Kurita K, Ogura K, Iwakura Y, Polymer, 19, 458 (1978)
Hillyard IW, Doczi J, Kiernam PB, Proc. Soc. Exp. Biol. Med., 115, 1108 (1964)

[Referenced By]

[1] Wolform ML, Madison RK, Cron MJ, J. Am. Chem. Soc., 74, 1491 (1952)

[2] Hackman RH, Austr. J. Biol. Sci., 7, 168 (1954)

[3] Kurida K, Sannan T, Iwakura Y, Makromol. Chem., 178, 3197 (1977)

[4] Miyazaki T, Matsushima Y, Bull. Chem. Soc. Jpn., 41, 2723 (1968)

[5] Nudge La, Plisko EA, Danilov SN, Zh. Obshch. Khim., 45, 1145 (1975)

[6] Kaifu K, Nishi N, Komai T, Polym. J., 13, 214 (1981)

[7] Jeuniaux C, Arch. Intern. Physiol. Biochem., 72, 329 (1964)

[8] Muzzarelli RAA, "Chitin," 46, Pergamon, New York (1977)

[9] Guy RH, Hadgraft J, "Drug Parameters Important for Transdermal Delivery," vol. III, 4 ~ 5, CRC Press, Florida (1987)

[10] Noonan PK, Bend LZ, Int. J. Pharm., 12(4-5), 331 (1982)

[11] Kim SI, Na JW, J. Korean Chem. Soc., 37, 527 (1993)

[12] Miayzaki S, Ishii K, Nodai T, J. Korean Chem. Soc., 29, 3067 (1981)

[13] Sawayanagi Y, Nambu N, Nagi T, J. Korean Chem. Soc., 31, 2064 (1983)

[14] Sheth PR, Tossounian JL, U.S. Patent, 4,140,755 (1990)

[15] Shalaby WSW, Blevins WE, Park KN, Proc. Int. Symp. Control. Rel. Bioact. Mater., 17, 134 (1990)

[16] Curatolo WJ, Lo J, Eur. Patent, 0,344,939 A2 (1992)

[17] Johson P, Lioyd-Jones JG, "Drug Delivery Systems," 107, Ellis Horwood, England (1984)

[18] Rouget C, Comp. Rend., 48, 792 (1859)

[19] Rigby GW, U.S. Patent, 2,072,771 (1936)

[20] Kim YM, Choi KS, Polym.(Korea), 9(5), 417 (1985)

[21] Wolfrom ML, ShenHan TM, J. Am. Chem. Soc., 81, 1764 (1959)

[22] Sannan T, Kurita K, Ogura K, Iwakura Y, Polymer, 19, 458 (1978)

[23] Hillyard IW, Doczi J, Kiernam PB, Proc. Soc. Exp. Biol. Med., 115, 1108 (1964)