In this study, La0.6Sr0.4Co0.8Ga0.2O3- (LSCG) hollow fiber membrane reactor was integrated with Ni/LaAlO3-Al2O3 catalyst for the catalytic partial oxidation of methane (POM) reaction. The process was successfully carried out in the medium temperature range (600-800 degrees C) for reaction of blank POM with bare membrane, catalytic POM reaction and swept with H-2:CO gas mixture. For the catalytic POM reaction, enhancement in selectivity to H-2 and CO is obtained between 650-750 degrees C when O-2:CH4 <1. High CH4 conversion of 97% is achieved at 750 degrees C with corresponding H-2 and CO selectivity of about 74 and 91%. The oxygen flux of the membranes also increased with the increase in oxygen partial pressure gradient across the membrane. The postreacted membranes were tested via XRD and FESEM-EDX for their crystallinity and surface morphology. XPS analysis was further used to investigate the O1s, Co 2p and Sr 3d binding energies of the segregated elements from the reducing reaction environment. (c) 2013 American Institute of Chemical Engineers AIChE J, 59: 3874-3885, 2013