In the previous paper, we proposed fundamental techniques to model and simulate combined continuous processes and discrete event systems, including sequential control, and developed a simulation program package for general use. In this paper, we apply the combined simulation method to analyze a proposed design of spinning processes in the synthetic fiber production plant. Repeated simulation is effectively used to make an appropriate decision on the number of equipment items. This case study includes various concrete techniques for modeling and simulation, and will help the process designer to model large-scale and complicated systems, and to analyze system performances.