Chemistry Letters, Vol.42, No.9, 975-976, 2013
Synthetic Study of Presilphiperfolan-8-ol: Construction of the Tricyclo[5.3.1.0(4,11)]undecane Framework Utilizing Intramolecular Aldol Condensation and McMurry Coupling
The tricyclo[5.3.1.0(4,11)]undecane framework of presilphiperfolan-8-ol, tricyclic sesquiterpene alcohol was constructed by intramolecular aldol condensation and the McMurry coupling from two types of diketone compounds, which were obtained from (+)-pulegone through a five-step process. This synthetic route does not require the use of any protective groups.