Effect of Scutellaria baicalensis extract on skin barrier function via peroxisome proliferator-activated receptor-α

Bora Kim; Jin Eun Kim; Su Min Lee; Hyun-Soo Kim

Korean Journal of Chemical Engineering, Vol.31, No.1, 104-108, January, 2014

DOI10.1007/s11814-013-0202-9 Export Citation

Effect of Scutellaria baicalensis extract on skin barrier function via peroxisome proliferator-activated receptor-α

Bora Kim, Jin Eun Kim, Su Min Lee, and Hyun-Soo Kim^{1, †}

R&D Center of Skin Science and Cosmetics, Enprani Co., Ltd., Incheon 400-103, Korea
¹Department of Food Science and Industry, Jungwon University, Chungbuk 367-805, Korea

E-mail:

Scutellaria baicalensis extract (SBE) was investigated to determine its effects on the transactivation activity of peroxisome proliferator-activated receptors (PPAR)-responsive element (PPRE) and anti-oxidant activity for improvement of skin barrier function. The treatment with SBE resulted in a significant increase in the transactivation activity of PPRE such as PPAR-α and effect in anti-oxidant and anti-microbial activity. In addition, SBE promotes the expression of protein related to cornified envelope (CE) formation such as involucrin. Therefore, these results indicate that SBE can promote keratinocyte differentiation and restore skin barrier homeostasis, and is suggested to be an appropriate skin therapeutic agent for improving epidermal permeability barrier function.

Keywords:Peroxisome Proliferators Activated Receptors;Anti-oxidative Activity;Scutellaria baicalensis Extract

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[1] Holleran WM, Takagi Y, Menon GK, Jackson SM, Lee JM, Feingold KR, Elias PM, J. Lipid Res., 35, 905 (1994)

[2] Downing DT, J. Lipid Res., 33, 301 (1992)

[3] Weber TM, Kausch M, Rippke F, Schoelermann AM, Filbry AW, J. Clin. Aesthet. Dermatol., 5(8), 29 (2012)

[4] Bissett DL, Clin. Dermatol., 27(5), 435 (2009)

[5] Schoonjans K, Staels B, Auwerx J, J. Lipid Res., 37, 907 (1996)

[6] Kersten S, Desvergne B, Wahli W, Nature., 405, 421 (2000)

[7] Kuenzli S, Saurat JH, Br. J. Dermatol., 149(2), 229 (2003)

[8] Dubrac S, Schmuth M, Dermatoendocrinol., 3, 23 (2011)

[9] Hanley K, Jiang Y, He SS, Friedman M, Elias PM, Bikle DD, Williams ML, Feingold KR, J. Clin. Invest., 110, 368 (1998)

[10] Komuves LG, Hanley K, Lefebvre AM, Man MQ, Ng DC, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR, J. Invest. Dermatol., 115(3), 353 (2000)

[11] Hanley K, Jiang Y, Crumrine D, Bass NM, Appel R, Elias PM, Williams ML, Feingold KR, J. Clin. Invest., 100(3), 705 (1997)

[12] Hatano Y, Elias PM, Crumrine D, Feingold KR, Katagiri K, Fujiwara S, J. Invest. Dermatol., 131(9), 1845 (2011)

[13] Yoon SB, Lee YJ, Park SK, Kim HC, Bae H, Kim HM, Ko SG, Choi HY, Oh MS, Park W, J. Ethnopharmacol., 125(2), 286 (2009)

[14] Kimura Y, Sumiyoshi M, Phytomedicine., 20(3-4), 328 (2013)

[15] Herzi N, Bouajila J, Camy S, Cazaux S, Romdhane M, Condoret JS, J. Food. Sci., DOI:10.1111/1750-3841.12113 (2013)

[16] Sharma KV, Sisodia R, J. Radiol. Prot., 29(3), 429 (2009)

[17] Kim SH, Nam GW, Lee HK, Moon SJ, Chang IS, Arch. Dermatol. Res., 298(6), 273 (2006)

[18] Rosa JS, Ross LA, Ong PY, Pediatr. Dermatol., DOI:10.1111/j.1525-1470.2012.01870.x (2012)

[19] Zandi K, Lim TH, Rahim NA, Shu MH, Teoh BT, Sam SS, Danlami MB, Tan KK, Abubakar S, BMC Complement.Altern. Med., 13, 91 (2013)

[20] Lam UDP, Hoang DN, Lee HB, Kim B, Lee JD, Shin JH, Kim EK, Korean J. Chem. Eng., 28(4), 1074 (2011)