Pressure distribution and wall shear stress in stenosis and abdominal aortic aneurysm by computational fluid dynamics modeling (CFD)

Jong-Beum Choi; Young-Ran Park; Shang-Jin Kim; Hyung-Sub Kang; Byung-Yong Park; In-Shik Kim; Yeong-Seok Yang; Gi-Beum Kim

Korean Journal of Chemical Engineering, Vol.31, No.3, 402-411, March, 2014

DOI10.1007/s11814-013-0215-4 Export Citation

Pressure distribution and wall shear stress in stenosis and abdominal aortic aneurysm by computational fluid dynamics modeling (CFD)

Jong-Beum Choi¹, Young-Ran Park², Shang-Jin Kim³, Hyung-Sub Kang³, Byung-Yong Park⁴, In-Shik Kim⁴, Yeong-Seok Yang⁵, and Gi-Beum Kim^{6, 7, †}

¹Chonbuk National University Medical Schools, Chonbuk National University, Duckjin-dong 1-Ga, Duckjin-gu, Jeonju 561-756, Korea
²Division of Chemical Engineering, College of Engineering, Chonbuk National University, Duckjin-dong 1-Ga, Duckjin-gu, Jeonju 561-756, Korea
³Department of Pharmacology, College of Veterinary Medicine, Korea Zoonosis Research Institute, Chonbuk National University, Duckjin-dong 1-Ga, Duckjin-gu, Jeonju 561-756, Korea
⁴Department of Veterinary Anatomy, College of Veterinary Medicine, Chonbuk National University, Duckjin-dong 1-Ga, Duckjin-gu, Jeonju 561-756, Korea
⁵Division of Pharmaceutical Engineering, Woosuk University, Samnye-ro, Samnye-eup, Wanju 565-701, Korea
⁶Chonbuk National University Medical Schools, HYOLIM E&I. Co., Ltd., Chonbuk National University, Duckjin-dong 1-Ga, Duckjin-gu, Jeonju 561-756, 72, Achasan-ro 78-Gil, Gwangjin-gu, Seoul 143-802, Korea
⁷Division of Chemical Engineering College of Engineering, Chonbuk National University, Duckjin-dong 1-Ga, Duckjin-gu, Jeonju 561-756, Korea

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The models of stenosed blood vessel with three different types of stenosis types have been modeled to investigate blood flow characteristics. The study was performed to investigate various hemodynamics, such as pressure and wall shear stress (WSS), with the change of stenosis ratio and Reynolds numbers (Re). The results of modeling, the minimum WSS occurred in different regions according to the stenosis types. The change of the diameter of blood vessel showed up in the pre-stenotic region by elastic behavior characteristics of blood vessels. Also, when the thickness of wall of blood vessel is 2 mm, the radius of blood vessel is increased by approximately two-times. As atherosclerosis progresses, the wall of blood vessels gradually loses elasticity and then the thickness of blood vessels gets thinner.

Keywords:Abdominal Aortic Aneurysm;Computational Fluid Dynamics (CFD);Atherosclerosis;Shear Stress

[References]

Giddens DP, Zarins CK, Glagov S, J. Biomech. Eng. T. ASME, 115, 588 (1993)
Lee BK, Kwon HM, Kim DS, Yoon YW, Seo JK, Kim IJ, Roh HW, Suh SH, Yoo SS, Kim HS, Yonsei Med. J., 39(2), 166 (1998)
Zendehbudi GR, Moayeri MS, J. Biomech., 32, 959 (1999)
Lee BK, Kwon HM, Hong BK, Park BE, Sug SH, Cho MT, Lee CS, Kim MC, Kim CJ, Yoo SS, Kim HS, Yonsei Med. J., 42(4), 375 (2001)
Kim HK, Park JC, Kim SS, Choi HS, Sim DS, Yoon NS, Yoon HJ, Hong YJ, Park HY, Kim JH, Yan YG, Korean J. Int. Med., 77, 68 (2009)
Ku DN, Giddens DP, Zarins CK, Glagov S, Arteriosclerosis, 5, 293 (1985)
Bluestein D, Alemu Y, Avrahami I, Gharib M, Dumont K, Ricotta JJ, Einav S, J. Biomech., 41, 1111 (2008)
Fry DL, A Ciba Foundation Symp., ASP, Amsterdam, The Netherlands, 40 (1972)
Caro CG, Fitz-Gerald FM, Schroter RC, Proc. R. Soc. B., 177, 109 (1971)
Thompson RW, Geraghty PJ, Lee JK, Curr. Prob. Surg., 39(2), 110 (2002)
Fillinger MF, Marra SP, Raghavan ML, Kennedy FE, J. Vasc. Surg., 37(4), 724 (2003)
Oh SE, Lee KR, J. Biomed. Eng. Res., 21(2), 181 (2000)
Valencia A, Villanueva M, Int. Commun. Heat Mass Transf., 33, 966 (2006)
Kim SJ, Park YR, Kim SJ, Kang HS, Kim JS, Oh SH, Kang SJ, Kim GB, JKAIS, 13(5), 2285 (2012)
Park YR, Kim SJ, Kim SJ, Kim JS, Kang HS, Kim GB, J. Biomed. Nanotechnol., 9, 1137 (2013)
Choi JH, Lee CS, Kim CJ, J. Biomed. Eng. Res., 21, 363 (1997)
Seo SH, Park JK, Roh HW, Lee BK, Kwon HM, Trans. KSME, B, 34(10), 893 (2010)
David NK, Ann. Rev. Fluid Mech., 29, 399 (1997)
Kirpalani A, Park H, Butany J, Johnston KW, J. Biomech. Eng., 121(4), 370 (1999)
Manimaran R, WASET, 49, 957 (2011)
Sud VK, Sekhon GS, Bull. Math. Biol., 47, 35 (1985)
Ro KC, Ryou HS, Korea-Aust. Rheol. J., 21(3), 175 (2009)
Li ZY, Gillard JH, J. Am. Coll. Cardiol., 52(6), 498 (2008)
Li ZY, Taviani V, Tang T, Sadat U, Young V, Patterson A, Graves M, Gillrd JH, BJR, 82, 39 (2009)
Wootton DM, Ku DN, Annu. Rev. Biomed. Eng., 1, 299 (1999)
Ojha M, J. Biomech., 26, 1379 (1993)
Mittal M, Simmons SP, Udaykumar HS, J. Biomech. Eng. T. ASME, 123, 325 (2001)
Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT, Circulation, 87, 1179 (1993)
Lee RT, Loree HM, Cheng GC, Lieberman EH, Jaramillo N, Schoen FJ, J. Am. Coll. Cardiol., 21, 777 (1993)
Li ZY, Howarth S, Trivedi RA, UK-I JM, Graves MJ, Brown A, Wang L, Gillard JH, J. Biomech., 39, 2611 (2006)
Li ZY, Howarth SP, Tang T, Gillard JH, Stroke, 37, 1195 (2006)
Li ZY, Howarth SP, Tang T, Graves MJ, UK-I JM, Trivedi RA, Kirkpatrick PJ, Gillard JH, J. Vasc. Surg., 45, 768 (2007)
MRC European Carotid Surgery, Lancet, 337, 1235 (1991)
North Americas Symptomatic Carotid Endarterectomy Trial collaborators, N. Eng. J. Med., 325, 445, 445 (1991)

[Related Articles]

[1] Giddens DP, Zarins CK, Glagov S, J. Biomech. Eng. T. ASME, 115, 588 (1993)

[2] Lee BK, Kwon HM, Kim DS, Yoon YW, Seo JK, Kim IJ, Roh HW, Suh SH, Yoo SS, Kim HS, Yonsei Med. J., 39(2), 166 (1998)

[3] Zendehbudi GR, Moayeri MS, J. Biomech., 32, 959 (1999)

[4] Lee BK, Kwon HM, Hong BK, Park BE, Sug SH, Cho MT, Lee CS, Kim MC, Kim CJ, Yoo SS, Kim HS, Yonsei Med. J., 42(4), 375 (2001)

[5] Kim HK, Park JC, Kim SS, Choi HS, Sim DS, Yoon NS, Yoon HJ, Hong YJ, Park HY, Kim JH, Yan YG, Korean J. Int. Med., 77, 68 (2009)

[6] Ku DN, Giddens DP, Zarins CK, Glagov S, Arteriosclerosis, 5, 293 (1985)

[7] Bluestein D, Alemu Y, Avrahami I, Gharib M, Dumont K, Ricotta JJ, Einav S, J. Biomech., 41, 1111 (2008)

[8] Fry DL, A Ciba Foundation Symp., ASP, Amsterdam, The Netherlands, 40 (1972)

[9] Caro CG, Fitz-Gerald FM, Schroter RC, Proc. R. Soc. B., 177, 109 (1971)

[10] Thompson RW, Geraghty PJ, Lee JK, Curr. Prob. Surg., 39(2), 110 (2002)

[11] Fillinger MF, Marra SP, Raghavan ML, Kennedy FE, J. Vasc. Surg., 37(4), 724 (2003)

[12] Oh SE, Lee KR, J. Biomed. Eng. Res., 21(2), 181 (2000)

[13] Valencia A, Villanueva M, Int. Commun. Heat Mass Transf., 33, 966 (2006)

[14] Kim SJ, Park YR, Kim SJ, Kang HS, Kim JS, Oh SH, Kang SJ, Kim GB, JKAIS, 13(5), 2285 (2012)

[15] Park YR, Kim SJ, Kim SJ, Kim JS, Kang HS, Kim GB, J. Biomed. Nanotechnol., 9, 1137 (2013)

[16] Choi JH, Lee CS, Kim CJ, J. Biomed. Eng. Res., 21, 363 (1997)

[17] Seo SH, Park JK, Roh HW, Lee BK, Kwon HM, Trans. KSME, B, 34(10), 893 (2010)

[18] David NK, Ann. Rev. Fluid Mech., 29, 399 (1997)

[19] Kirpalani A, Park H, Butany J, Johnston KW, J. Biomech. Eng., 121(4), 370 (1999)

[20] Manimaran R, WASET, 49, 957 (2011)

[21] Sud VK, Sekhon GS, Bull. Math. Biol., 47, 35 (1985)

[22] Ro KC, Ryou HS, Korea-Aust. Rheol. J., 21(3), 175 (2009)

[23] Li ZY, Gillard JH, J. Am. Coll. Cardiol., 52(6), 498 (2008)

[24] Li ZY, Taviani V, Tang T, Sadat U, Young V, Patterson A, Graves M, Gillrd JH, BJR, 82, 39 (2009)

[25] Wootton DM, Ku DN, Annu. Rev. Biomed. Eng., 1, 299 (1999)

[26] Ojha M, J. Biomech., 26, 1379 (1993)

[27] Mittal M, Simmons SP, Udaykumar HS, J. Biomech. Eng. T. ASME, 123, 325 (2001)

[28] Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT, Circulation, 87, 1179 (1993)

[29] Lee RT, Loree HM, Cheng GC, Lieberman EH, Jaramillo N, Schoen FJ, J. Am. Coll. Cardiol., 21, 777 (1993)

[30] Li ZY, Howarth S, Trivedi RA, UK-I JM, Graves MJ, Brown A, Wang L, Gillard JH, J. Biomech., 39, 2611 (2006)

[31] Li ZY, Howarth SP, Tang T, Gillard JH, Stroke, 37, 1195 (2006)

[32] Li ZY, Howarth SP, Tang T, Graves MJ, UK-I JM, Trivedi RA, Kirkpatrick PJ, Gillard JH, J. Vasc. Surg., 45, 768 (2007)

[33] MRC European Carotid Surgery, Lancet, 337, 1235 (1991)

[34] North Americas Symptomatic Carotid Endarterectomy Trial collaborators, N. Eng. J. Med., 325, 445, 445 (1991)