화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.22, No.6, 639-646, June, 2014
DOI10.1007/s13233-014-2095-9  Export Citation
Comparison of Sirolimus Loaded PLGA-PEG Co-Polymer Coronary Stent and Bare Metal Stent in a Porcine Coronary Restenosis Model
Kyung Seob Lim1, 2, Jun-Kyu Park3, Myung Ho Jeong1, 2, †, Jae-Woon Nah3, †, Dong-Gon Kim3, In Ho Bae1, 2, Dae Sung Park1, 2, Jong Min Kim1, 2, Jung Ha Kim1, 2, Dong Lyun Cho1, 2, Doo Sun Sim1, 2, Keun-Ho Park1, 2, Young Joon Hong1, 2, and Youngkeun Ahn1, 2
  • 1Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, 500-757, Korea
  • 2Korea Cardiovascular Stent Institute of Chonnam National University, Gwangju, 500-757, Korea
  • 3Department of Polymer Science and Engineering, Sunchon National University, Jeonnam, 540-742, Korea
E-mail:,
The aim of this study was to compare the effect of the sirolimus loaded PLGA-PEG co-polymer coronary stent with that of the bare metal stent in a porcine coronary restenosis model. Pigs were randomized into two groups (10 pigs, 10 coronary arteries in each group), in which either the sirolimus loaded PLGA-PEG copolymer stent (SPPS, n=10) or the bare metal stent (BMS, n=10) was implanted in the coronary arteries. Histopathologic analysis was performed at 28 days after stenting. There were no significant differences in the injury score, internal elastic lamina (IEL) area, and inflammation score between the two groups. There were significant differences in the lumen area (3.6±0.42 mm2 in the SPPS group vs. 2.5±0.89 mm2 in the BMS group, p<0.001), in the neointimal area (1.2±0.34 mm2 in the SPPS group vs. 2.5±0.99 mm2 in the BMS group, p<0.001), in the percent area stenosis (26.0±6.58% in the SPPS group vs. 48.6±16.95% in the BMS group, p<0.001) and in the fibrin score (1.2±0.41 in the SPPS group vs. 0.5±0.26 in the BMS group, p<0.001). These results demonstrate that SPPS had a superior effect on suppression of neointimal hyperplasia than BMS at one month after stenting in a porcine coronary restenosis model.
Keywords:stents;percutaneous coronary intervention;restenosis;inflammation.
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