Chitosan-coated liposomes for enhanced skin permeation of resveratrol

Soo Nam Park; Na Rae Jo; So Ha Jeon

Journal of Industrial and Engineering Chemistry, Vol.20, No.4, 1481-1485, July, 2014

DOI10.1016/j.jiec.2013.07.035 Export Citation

Chitosan-coated liposomes for enhanced skin permeation of resveratrol

Soo Nam Park^†, Na Rae Jo, and So Ha Jeon

Department of Fine Chemistry, Nanobiocosmetic Laboratory, and Cosmetic R&D Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 139-743, Republic of Korea

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In this study, chitosan-coated liposomes were investigated for use in enhanced transdermal delivery of resveratrol. Particle size, entrapment efficiency, stability, and skin-permeation efficiency were evaluated. The particle size was seen to increase on coating with chitosan, with higher concentrations of coating solution forming larger particles. The zeta potential of the liposomes also followed the same trend, i.e., it changed from a negative value for uncoated liposomes to increasingly positive values for the chitosan-coated ones. The chitosan coating was seen to increase the stability of the liposomes by preventing their aggregation. Transdermal delivery of uncoated and 0.1% chitosan-coated liposomes containing 0.1% resveratrol was investigated using Franz diffusion cells. The proportions of resveratrol that permeated the animal skin were 40.42% and 30.84% for the coated and uncoated liposomes, respectively. This increased skin-permeation efficiency with the coating could be explained by the tendency of positively charged liposomes to interact more strongly with the skin surface. These results indicate that chitosan-coated liposomes could be an effective transdermal delivery system for delaying skin aging using resveratrol.

Keywords:Resveratrol;Liposome;Chitosan coating;Skin permeation

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[2] De la Lastra CA, Villegas I, Mol. Nutr. Food Res., 49, 405 (2005)

[3] Wolter F, Stein J, Drugs Fut., 27, 949 (2002)

[4] Chan MMY, Biochem. Pharmacol., 63, 99 (2002)

[5] Docherty JJ, Smith JS, Fu MM, Stoner T, Booth T, Antiviral Res., 61, 19 (2004)

[6] Kolouchova I, Melzoch K, Smidrkal Filip J, Chemick. Listy, 99, 492 (2005)

[7] Shi G, Rao L, Yu H, Xiang H, Yang H, Ji H, Pharm. Int. J., 349, 83 (2008)

[8] Hasanovic A, Hollick C, Fischinger K, Valenta C, Eur. J. Pharm. Biopharm., 75, 148 (2010)

[9] Wang YW, Jou CH, Hung CC, Yang MC, Colloids Surf. B: Biointerfaces, 90, 169 (2012)

[10] Pajean M, Huc A, Herbage D, Int. J. Pharm., 77, 31 (1991)

[11] Takeuchi H, Kojima H, Yamamoto H, Kawashima Y, Control Release J., 8, 195 (2000)

[12] Hasanovic A, Zehl M, Reznicek G, Valenta C, J. Pharm. Pharmacol., 61, 1609 (2009)

[13] Perugini P, Genta I, Pavanetto F, Conti B, Scalia S, Baruffini A, Pharm. Int. J., 196, 51 (2000)

[14] Guo J, Ping Q, Jiang G, Huang L, Tong Y, Pharm. Int. J., 260, 167 (2003)

[15] Zaru M, Manca ML, Fadda AM, Antimisiaris SG, Colloids Surf. B: Biointerfaces, 71, 88 (2009)

[16] Schonhoff M, J. Phys. Condens. Matter, 15, 1781 (2003)

[17] Guzey D, McClements DJ, Adv. Colloid Interface Sci., 128-130, 227 (2006)

[18] Madrigal-Carballo S, Lim SW, Rodriguez G, Vila AO, Krueger CG, Gunasekaran S, Reed JD, Funct. Foods J., 2, 99 (2010)

[19] Paolino D, Fresta M, Sinha P, Ferrari M, in: Webester JG (Ed.), 2nd ed., Encyclopedia of Medical Devices and Instrumentation, vol. 437, John Wiley and Sons, New York, 2006.

[20] Yilmaz E, Borchert HH, Eur. J. Pharm. Biopharm., 60, 91 (2005)

[21] Rojanasakul Y, Wang LY, Bhat M, Glover DD, Malanga CJ, Ma JK, Pharm. Res., 9, 1029 (1992)

[22] Piemi MP, Korner D, Benita S, Marty JP, J. Control Release, 58, 177 (1999)