Comparison of single-drop microextraction with microvolume pipette extraction directly coupled with capillary electrophoresis for extraction and separation of tricyclic antidepressant drugs

Hui-Fen Wua; Suresh Kumar Kailasa; Ja-Yi Yan; Chen-Che Chin; Hsin-Yi Ku

Journal of Industrial and Engineering Chemistry, Vol.20, No.4, 2071-2076, July, 2014

DOI10.1016/j.jiec.2013.09.034 Export Citation

Comparison of single-drop microextraction with microvolume pipette extraction directly coupled with capillary electrophoresis for extraction and separation of tricyclic antidepressant drugs

Hui-Fen Wua^{1, 2, †}, Suresh Kumar Kailasa^{1, 2}, Ja-Yi Yan³, Chen-Che Chin³, and Hsin-Yi Ku^{1, 4}

¹Department of Chemistry, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
²Center for Nanoscience and Nanotechnology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
³Department of Chemistry, Tamkang University, Tamsui, New Taipei 251, Taiwan
⁴, Taiwan

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This paper describes the use of single-drop microextraction and micro-volume pipette extraction coupled with capillary electrophoresis for the analysis of five antidepressant drugs (nortriptyline, imipramine, trimeprazine, promethazine, and iminodibenzyl). The five antidepressant drugs are well separated by using micellar electrokinetic capillary chromatography with SDS and organic modifiers. The best extraction was achieved within 10 min and effectively separated within 15 min by using ammonium acetate buffer at 28 kV. This method shows good reproducibility, with RSD values ranging from 4.3 to 8.7%. The LODs values were found to be 0.4 and 1.0 μg mL-1 for SDME-CE and 0.15 and 0.5 μg mL-1 for MVPE-CE. These methods are simple, rapid, sensitive and efficient for the extraction, separation and detection of tricyclic antidepressant drugs.

Keywords:Tricyclic antidepressant drugs;SDME;MVPE;Buffer;Voltage;CE

[References]

Veuthey JL, Anal. Biochem., 381, 93 (2005)
Nemeth K, Tarkanyi G, Varga E, Imre T, Mizsei R, Ivanyi R, Visy J, Szeman J, Jicsinszky L, Szente L, Simonyi M, J. Pharm. Biomedical Anal., 54, 475 (2011)
Prokhorov AF, Shapovalov EN, Shpigun OA, J. Pharm. Biomedical Anal., 53, 1170 (2010)
Faria AF, de Souza MVN, Bruns RE, de Oliveira MAL, Talanta, 82, 333 (2010)
Bai BC, Cho S, Yu HR, Yi KB, Kim KD, Lee YS, J. Ind. Eng. Chem., 19(3), 776 (2013)
Shamsabadi AA, Kargari A, Babaheidari MB, Laki S, Ajami H, J. Ind. Eng. Chem., 19(2), 677 (2013)
Cheng HL, Chiou SS, Liao YM, Lu CY, Chen YL, Wu SM, Anal. Biochem., 398, 2183 (2010)
Lin SC, Whang CW, J. Sep. Sci., 31, 3921 (2008)
Spencer BJ, Zhang W, Purdy WC, Electrophoresis, 18, 736 (1997)
Brunt NV, Therapeutic Drug Monitoring, 5, 1 (1983)
Gupta RN, Stefanec M, Eng F, Clin. Biochem., 16, 94 (1983)
Rovei V, Sanjuan M, Hrdina PD, J. Chromatogr., 182, 349 (1980)
Koteel P, Mullins RE, Gadsden RH, Clin. Chem., 28, 462 (1982)
Breutzmann DA, Bowers LD, Clin. Chem., 27, 1907 (1981)
Titier K, Castaing N, Le-Deodic M, Le-Bars D, Moore N, Molimard M, J. Anal. Toxicol., 31, 200 (2007)
Breaud AR, Harlan R, Kozak M, Clarke W, Clinical Biochem., 42, 1300 (2009)
Chinn DM, Jennison TA, Crouch DJ, Peat MA, Thatcher GM, Clinical Chem., 26, 1201 (1989)
Cantu MD, Hillebrand S, Queiroz MEC, Lancasa FM, Carrilho E, J. Chromatogr. B, 799, 127 (2004)
Han D, Row KH, Microchimica Acta, 176, 1 (2012)
Kataoka H, Anal. Bioanal. Chem., 96, 339 (2010)
Yazdi AS, Razavi N, Yazdinejad SR, Talanta, 75, 1293 (2008)
Gupta M, Jain A, Verma KK, J. Sep. Sci., 33, 3774 (2010)
Veraart JR, Th Brinkman UA, J. Chromatogr. A, 922, 339 (2001)
Alves C, Santos-Neto AJ, Fernandes C, Rodrigues JC, Lancas FM, J. Mass Spectrometry, 42, 1342 (2007)
Khodari M, Mansour H, El-Din HS, Anal. Lett., 30, 1909 (1997)
Psillakis E, Kalogerakis N, J. Chromatogr. A, 907, 211 (2001)
Keith LH, Grummett W, Deegan J, Libby RA, Taylor JK, Wentler G, Anal. Chem., 55, 2210 (1983)

[1] Veuthey JL, Anal. Biochem., 381, 93 (2005)

[2] Nemeth K, Tarkanyi G, Varga E, Imre T, Mizsei R, Ivanyi R, Visy J, Szeman J, Jicsinszky L, Szente L, Simonyi M, J. Pharm. Biomedical Anal., 54, 475 (2011)

[3] Prokhorov AF, Shapovalov EN, Shpigun OA, J. Pharm. Biomedical Anal., 53, 1170 (2010)

[4] Faria AF, de Souza MVN, Bruns RE, de Oliveira MAL, Talanta, 82, 333 (2010)

[5] Bai BC, Cho S, Yu HR, Yi KB, Kim KD, Lee YS, J. Ind. Eng. Chem., 19(3), 776 (2013)

[6] Shamsabadi AA, Kargari A, Babaheidari MB, Laki S, Ajami H, J. Ind. Eng. Chem., 19(2), 677 (2013)

[7] Cheng HL, Chiou SS, Liao YM, Lu CY, Chen YL, Wu SM, Anal. Biochem., 398, 2183 (2010)

[8] Lin SC, Whang CW, J. Sep. Sci., 31, 3921 (2008)

[9] Spencer BJ, Zhang W, Purdy WC, Electrophoresis, 18, 736 (1997)

[10] Brunt NV, Therapeutic Drug Monitoring, 5, 1 (1983)

[11] Gupta RN, Stefanec M, Eng F, Clin. Biochem., 16, 94 (1983)

[12] Rovei V, Sanjuan M, Hrdina PD, J. Chromatogr., 182, 349 (1980)

[13] Koteel P, Mullins RE, Gadsden RH, Clin. Chem., 28, 462 (1982)

[14] Breutzmann DA, Bowers LD, Clin. Chem., 27, 1907 (1981)

[15] Titier K, Castaing N, Le-Deodic M, Le-Bars D, Moore N, Molimard M, J. Anal. Toxicol., 31, 200 (2007)

[16] Breaud AR, Harlan R, Kozak M, Clarke W, Clinical Biochem., 42, 1300 (2009)

[17] Chinn DM, Jennison TA, Crouch DJ, Peat MA, Thatcher GM, Clinical Chem., 26, 1201 (1989)

[18] Cantu MD, Hillebrand S, Queiroz MEC, Lancasa FM, Carrilho E, J. Chromatogr. B, 799, 127 (2004)

[19] Han D, Row KH, Microchimica Acta, 176, 1 (2012)

[20] Kataoka H, Anal. Bioanal. Chem., 96, 339 (2010)

[21] Yazdi AS, Razavi N, Yazdinejad SR, Talanta, 75, 1293 (2008)

[22] Gupta M, Jain A, Verma KK, J. Sep. Sci., 33, 3774 (2010)

[23] Veraart JR, Th Brinkman UA, J. Chromatogr. A, 922, 339 (2001)

[24] Alves C, Santos-Neto AJ, Fernandes C, Rodrigues JC, Lancas FM, J. Mass Spectrometry, 42, 1342 (2007)

[25] Khodari M, Mansour H, El-Din HS, Anal. Lett., 30, 1909 (1997)

[26] Psillakis E, Kalogerakis N, J. Chromatogr. A, 907, 211 (2001)

[27] Keith LH, Grummett W, Deegan J, Libby RA, Taylor JK, Wentler G, Anal. Chem., 55, 2210 (1983)