비수유화법에 의한 미세 O/W에멀젼의 특성

이성준; 노윤찬; 강윤석; 남기대

Journal of the Korean Industrial and Engineering Chemistry, Vol.7, No.1, 145-152, February, 1996

Export Citation

비수유화법에 의한 미세 O/W에멀젼의 특성

The Characteristics of a Fine O/W Emulsion by Nonaqeous Emulsification

이성준, 노윤찬, 강윤석, 남기대

초록

비수유화법을 이용한 미세 O/W에멀젼의 제조 기술에 관한 연구로 표면장력, 계면장력, 탁도 및 전이온도를 통하여 비수용매/기름에서의 POE(25)octyldodecyl ether의 거동을 연구하였다. POE(25)octyldodecyl ether는 물 용매에서의 미셀 형성과는 달리 비수용매에서는 용해되었다. 글리세린과 같은 용매에서는 POE(25)octyldodecyl ether의 용해력은 약했으며 표면으로 이동되었다. 표면에서 포화된 후 POE(25)octyldodecyl ether는 석출 현상을 보였다. 최종 에멀젼의 평균입자 크기는 230nm 이었으며 한달 동안의 0, 25, 40, 50℃ 및 순환시험에 안정하였으나 일반적인 에멀젼은 불안정하였다. 따라서 적절한 용매의 조합에 의해 계면활성제의 흡착 효율을 증가시킬 수 있었다.

A fine oil-in-water (O/W) emulsion using nonaqueous emulsification technique was developed and the behaviors of POE(25)octyldodecyl ether in nonaqueous solvent/oil systems were studied by observing the surface tension, interfacial tension, turbidity and transition temperature. It was found that POE(25)octyldodecyl ether existed soluble in nonaqueous solvent while, in aqueous system, it formed micelles. So, when a solvent, like glycerine in which POE(25)octyldodecyl ether has poor solubility, was added, POE(25)octyldodecyl ether moved to the surface. After saturated at surface, POE(25) octyldodecyl ether began to precitate. The mean particle size of the final emulsion was 230nm. Also, the emulsion system was stable at 0, 25, 40, 50℃ and cycling test for a month, while the conventional emulsion system showed unstability. It is concluded that, by pertinent combination of solvents, the adsorption efficiency of surfactant could be improved.

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[1] Shinoda K, Saito H, J. Colloid Interface Sci., 30, 258 (1969)

[2] Shinoda K, Saito H, J. Colloid Interface Sci., 32, 647 (1967)

[3] Sagatini H, J. Am. Oil Chem. Soc., 58, 738 (1981)

[4] Griffin WC, J. Soc. Cosmetic Chemists, 5, 249 (1954)

[5] Peterson RV, Hamill RD, J. Soc. Cosmetic Chemists, 19, 627 (1968)

[6] Mcmahon JD, Hamill RD, J. Pharm. Sci., 52, 12 (1963)

[7] Peterson RV, Mcmahon JD, J. Pharm. Sci., 53, 6 (1964)

[8] Peterson RV, Hamill RD, J. Pharm. Sci., 55, 11 (1966)

[9] Peterson RV, Hamill RD, J. Pharm. Sci., 54, 4 (1965)

[10] Curme GO, Johnston F, "Glycols," Reihold Publishing Co., New York (1952)

[11] Schick MJ, Fowkes FM, J. Phys. Chem., 61, 1062 (1957)

[12] McNicoll BJ, Schreiber HP, "Solution Chemistry of Surfactants," Wiley, New York, 1, 367 (1979)

[13] Magdassi S, Frank SG, J. Dispersion Sci. Tech., 7, 3 (1986)

[14] Noy D, "Surface Equilibris of Colloids," J.J. Little and Ives Co., New York (1926)

[15] Myers D, "Surface Interface and Colloids," VCH Publishers Inc., 305 (1991)