In this work, novel catalyst frameworks including Mn/TiO2-CeO2, Cu/TiO2-CeO2, Mn-Ce-O, Mn-Cu-O, and TiO2-CeO2 were investigated for the catalytic wet peroxide oxidation of phenol-like pollutants. Aiming to gain further insights into the heterogeneous catalysis of manganese and copper metals supported on titanium and cerium oxides, the abatement efficiency was evaluated under different operating conditions and in terms of individual phenolic compounds depletion. Here, Mn/TIO2-CeO2 was found as the most active promoter for the highest detoxification rate. Second, pH profiles and reaction intermediates unveiled a free-radical mechanism and underlined the synergism behavior in catalytic wet peroxide oxidation. The titanium based oxides exhibited the strongest catalytic stability by the quantification of metal leaching and carbon adsorption. Afterwards, the integrated metal framework encompassed by Mn/TiO2-CeO2 and Cu/TiO2-CeO2 catalysts was realized in X-ray diffraction analysis and the TEM pattern gave rise to superior homogenous structures for Mn/TiO2-CeO2, which has been ascribed to the integration of the lanthanide into the lattice framework of titanium oxide. Finally, several sequential feed-batch trials were carried out emphasizing that 67% of pollutant conversion can be retained after long term catalytic runs. (c) 2012 Elsevier B.V. All rights reserved.