This paper presents theoretical investigations into a hybrid ejector and CO2 vapour compression (VC) system for road transport cooling. The purpose is to utilise the waste heat from exhaust gas and the VC subsystem to drive the ejector system, whose cooling effect will be employed to subcool the VC sub-system. Exploitation of the energy consumption ratio between ejector sub-system and CO2 VC sub-system indicated that the more energy obtained from exhausted gas, the better system performance could be achieved for CO2 VC sub-system, and hence higher cooling capacity of the VC sub-system at the same compression power. Thermodynamic simulations of two sub-systems and the hybrid system were presented. The results indicated that, at boiler temperature of 120 degrees C, evaporator temperature of 10 degrees C, a COP of 0.584 was achieved for hybrid system, with 22% improvement over a single ejector cycle. Preliminary experimental studies were carried out on a single ejector cycle, with boiler temperatures between 115 degrees C and 130 degrees C, and evaporator temperatures between 5 degrees C and 10 degrees C. The effects of various operation conditions on the overall ejector operation were coherently analysed. The COP of the ejector sub-system from experimental results was approximately 85% compared with simulation results, which showed a good agreement between theoretical analysis and experimental results. (c) 2012 Elsevier Ltd. All rights reserved.