The purpose of this study was to evaluate the use of the biodegradable poly(l-lactide) (PLLA) as a gastro-jejunal tube anchored in the duodenum for duodenal exclusion. PLLA film was fabricated using a hot melting process to a thickness of around 40-50 mu m and was then immersed in human gastric juice to estimate the in vitro biodegradability behavior. PLLA film was more biodegradable in human gastric juice than in HCl and PBS. Measurements of weight loss indicated that 60% of original the PLLA was lost after 42 days of incubation. Surface functional group characterization, thermal stability, and surface morphology of the degraded PLLA film in human gastric juice showed that the decomposed sections of the PLLA film were primarily from the amorphous region. The degradation of the PLLA film in human gastric juice began with the erosion of continuous nanocavities in the range of 100-200 nm on the PLLA surface over the course of 21 days. The PLLA film collapsed and spiral PLLA fiber was obtained after 42 days of decomposing in human gastric juice. (c) 2012 Elsevier B.V. All rights reserved.