Titanium and its alloys have been commonly used in many biological and industrial applications owing to their excellent mechanical and physical properties. However, they have been specifically inadequate for biomedical implants due to their inferior tribological properties (low wear resistance, higher coefficient of friction, and lower hardness). As a remedy, the process of laser nitriding has emerged from the past few decades as a unique method for tailoring the surface microstructures and/or composition of titanium for enhanced tribological characteristics of titanium and its alloys. In the present study, a multiphysics computational model was developed to predict the nitrogen diffusion length into the Ti-6Al-4V alloy under various laser processing conditions (laser power and scanning speed). XRD, SEM and EDS analyses were also conducted for phase identification, microstructural investigation, and estimating the nitrogen concentration, respectively. Both computational and experimental results indicated that the depth of nitrogen diffusion increased with decrease in scanning speed, and subsequent increase in laser interaction time and increase in input laser energy density. (C) 2013 Elsevier B.V. All rights reserved.