Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

Venhoranta H; Li S; Salmon S; Flisikowska T; Andersson M; Switonski M; Kind A; Schnieke A; Flisikowski K

Biochemical and Biophysical Research Communications, Vol.444, No.3, 391-394, 2014

DOI10.1016/j.bbrc.2014.01.071 Export Citation

Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses

Venhoranta H, Li S, Salmon S, Flisikowska T, Andersson M, Switonski M, Kind A, Schnieke A, Flisikowski K

The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3' end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain. (C) 2014 Elsevier Inc. All rights reserved.

Keywords:Non-CpG methylation;Epigenetic regulation;Intrauterine growth restriction;PEG3;Mammalian DNA