The influence of seed addition temperature, seed surface area, and seeds of different origin on granulometric characteristics and polymorphism of glycine was examined. At sufficient surface seed area, a regular and narrow crystal size distribution (CSD) was obtained. Polymorphism was investigated by differential scanning calorimetry and X-ray diffraction analysis. Differences in seed size and seed mass couple affected the granulometric properties but did not cause changes in polymorphic structure. Four experiments with different origin seeds were carried out under optimal process conditions determined by preliminary experiments. Various seed origins caused differences in supersaturation level and CSD but the structure of the obtained crystals remained the same as the loaded seed.