Taylor-Couette flows between two concentric cylinders have great potential applications in chemical engineering. They are particularly convenient for two-phase small scale devices enabling solvent extraction operations. An experimental device was designed with this idea in mind. It consists of two concentric cylinders with the inner one rotating and the outer one fixed. Moreover, a pressure driven axial flow can be superimposed. Taylor-Couette flow is known to evolve towards turbulence through a sequence of successive hydrodynamic instabilities. Mixing characterized by an axial dispersion coefficient is extremely sensitive to these flow bifurcations, which may lead to flawed modelling of the coupling between flow and mass transfer. This particular point has been studied using experimental and numerical approaches. Direct numerical simulations (DNS) of the flow have been carried out. The effective diffusion coefficient was estimated using particles tracking in the different Taylor-Couette regimes. Simulation results have been compared with literature data and also with our own experimental results. The experimental study first consists in visualizing the vortices with a small amount of particles (Kalliroscope) added to the fluid. Tracer residence time distribution (RTD) is used to determine dispersion coefficients. Both numerical and experimental results show a significant effect of the flow structure on the axial dispersion. (C) 2012 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.