The solubility data of diosgenin in mixed systems of ethanol + 1-propanol (1 : 1), ethanol + 1-butanol (1 : 1), ethanol + isobutyl alcohol (1 : 1), methanol + isobutyl alcohol (1 : 1), methanol + isobutyl alcohol (1 : 4), ethanol + 1-pentanol (1 : 1) and carbon tetrachloride were measured over the temperature range from 289.15 K to 334.15 K by a laser monitoring observation technique at atmospheric pressure, with all mixtures mixed by volume ratio. The Apelblat equation, the ideal solution model, and the lambda h equation are used to correlate the solubility data. The results show that the three models agree well with the experimental data, providing essential support for industrial design and further theoretical study.