A slow bromination process of butyl rubber (IIR) suffers from low efficiency and low selectivity (S) of target-product. To obtain suitable approach to intensify the process, effects of assistant solvents and mixing intensity on the bromination process were systemically studied in this paper. The reaction process was found constantly accelerated with the increasing dosage and polarity of assistant solvent. Hexane with 30% (by volume) dichloromethane was found as the suitable solvent component, where the stable conversion of 1,4-isoprene transferring to target product (x(A1s)) of 80.2% and the corresponding S of 91.2% were obtained in 5 min. The accelerated reaction process was demonstrated being remarkably affected by mixing intensity until the optimal stirring rate of 1100 r min(-1) in a stirred tank reactor. With better mixing condition, a further intensification of the process was achieved in a rotating packed bed (RPB) reactor, where x(A1s) of 82.6% and S of 91.9% were obtained in 2 min. The usage of the suitable solvent component and RPB has potential application in the industrial bromination process intensification.